Endocrine Abstracts

Depression can be an early manifestation of Cushing Syndrome (CS) and found to correlate with the severity of the clinical presentation. Rates for major depression vary from 12% to 50–70%. A 37-year-old male was admitted for sad mood, affective lability, suicidal ideation without a plan and micromanian incurability ideation. The medical history of the patient revealed an old anterior-lateral myocardial infarction last year, with percutaneous coronary intervention on diago...

Adrenal incidentalomas (prevalence between 0.4 and 7%) have become a very common clinical problem, the major concern being the risk of malignancy and hormone overproduction.A 57-year-old woman was admitted for asthenia and uncontrolled hypertension. The only relevant clinical signs were abdominal obesity (BMI=31.1 kg/m2) and hypertension. Abdominal ultrasonography showed a voluminous left adrenal solid mass of 10/9 cm, with well-defined sharp ...

Multiple endocrine neoplasia 2A (MEN2A), an autosomal dominant genetic syndrome caused by germline mutation in RET proto-oncogene, associates medullary thyroid carcinoma (MTC), pheochromocytoma (PHEO) and primary hyperparathyroidism (HPT). Thyroid hemiagenesis (TH), the absence of one lobe, is a rare congenital abnormality (300 cases are reported in literature). Most cases of TH are diagnosed when patients present a lesion in the functioning lobe. TH was observed among members...

Autoimmune Polyglandular Syndrome Type I (APS 1) is a rare monogenic disease, in which simultaneous or sequential dysfunctions of endocrine or nonendocrine glands appear. A 19-year-old woman was admitted for inappetence, nausea, vomiting, abdominal pain, chronic constipation, generalized paresthesia and vertigo. She was known with primary hypoparathyroidism (from the age of 5), chronic autoimmune thyroiditis, mucocutaneous candidiasis, under treatment with calcitriol, calcium,...

Primary hyperparathyroidism (PHPT) is rarely associated with the development of acute pancreatitis (AP). The incidence of AP induced by hypercalcemia in PHPT varies between 1.5 and 7%. PHPT is most commonly caused by parathyroid adenoma and infrequently by parathyroid hyperplasia, carcinoma or cyst and multiple endocrine neoplasia (MEN) types 1 and 2A. The present case is a 48-year-old man referred to our service for further investigation 1 month after an acute hemorrhagic nec...